Influence of Fatty-Acid Composition of Infant Formulas on the Development of Arteriosclerosis and on the Lipid Composition of Blood and Tissues

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Abstract
Six liquid diets, widely varying in linoleate content, were fed to 50 infant rhesus monkeys. Some were transferred to monkey chow, and some of these to a high hydrogenated fat plus 2% corn oil diet. Our results confirm the previously reported hypercholesterolemic effect of bovine butterfat and the protective effect of linoleate against such hypercholesterolemia. Animals given large amounts of linoleate in their diets reflected this in the pattern of their blood and tissue fatty acids. However, judging by the erythrocyte and tissue levels of arachidonic acid, they tended to convert a smaller percentage of the total linoleate to arachidonate than animals reveiving considerably smaller amounts of linoleate. This was true whether the animals were infants, adolescents, or approaching sexual maturity.

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