The Induction of Immunological Tolerance During the Primary Response

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Abstract
By injecting adult guinea pigs intravenously with dinitrochlo-robenzene sulfonate (DNBSO3) 2 to 24 h after applying a sensitizing epicutaneous dose of dinitrochlorobenzene (DNCB), the production of PCA-detectable anti-DNP antibodies and the induction of contact hypersensitivity to DNCB is strongly depressed for over 14 weeks. The proportion of animals acquiring this state of specific unresponsiveness as well as its stability against a second sensitizing attempt with DNCB alone are clearly dependent on the dose of DNBSO3 injected and on the time interval elapsing between both hapten applications. However, the tolerogenic effect of DNBSO3 is stronger when injected some weeks before sensitization. The results obtained are discussed on the basis of current concepts on the relationship between antigen and immunocompetent cells. The possibilities to interpret our findings by means of reversible blocking or affinity labelling of cellular receptors, specific annihilation of antigen-sensitive cells or immune deviation are considered.

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