TRANSFORMATION INDUCED BY SIMIAN VIRUS 40 IN HUMAN RENAL CELL CULTURES, II. CELL-VIRUS RELATIONSHIPS
- 1 August 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (8) , 1350-1357
- https://doi.org/10.1073/pnas.48.8.1350
Abstract
Cell-virus relationships have been studied during the course of the cytolytic, proliferative, and transforming changes that occur in primary human renal cell cultures infected with SV40 virus. In such cultures, viral infectivity titers had attained maxima by the 25th to the 41st post-inoculation day and thereafter remained constant during 9-16 weeks. The cytopathogenic and cell-transforming capacities of the virus were approximately equivalent. Interferon was not demonstrated in these chronically infected cell systems. As compared to cells in uninfected cultures, transformed cells in subcultures exhibited increased resistance to injury by SV40 and an altered cytopathic response to infection with several RNA viruses.Authors.Keywords
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