THE EFFECTS OF ALKYL-LYSOPHOSPHOLIPIDS ON LEUKEMIC-CELL LINES .1. DIFFERENTIAL ACTION ON 2 HUMAN-LEUKEMIC CELL-LINES, HL60 AND K562
- 1 January 1981
- journal article
- research article
- Vol. 57 (4) , 794-797
Abstract
The action of an alkyl-lysophospholipid (ALP), ET180CH3 [an antineoplastic drug], on clonogenicity, 3H-TdR [thymidine] uptake and cell numbers was tested in 2 human leukemic cell lines, HL60 and K562, and short-term human leukemic bone marrow cultures. ALP eliminated clonigenicity in HL60 but not in K562 cultures; 3H-TdR uptake and cell numbers were depressed at low concentrations of ET180CH3 in HL60 but not K562 cultures. The action of the lysophospholipid analog on human leukemic bone marrow short-term cultures at low concentrations was similar to its action on HL60 cultures; clonogenicity and 3H-TdR uptake were depressed but cell numbers were not significantly affected. The demonstration of differential action of ALP on 2 cell lines should simplify investigation of the mechanism of the differential action of ET180CH3 on normal and leukemic cell membranes.This publication has 5 references indexed in Scilit:
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