ORGAN DISTRIBUTION OF CANINE LEUKOCYTES LABELED WITH TC-99M-SULFUR COLLOID

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (3) , 289-295
Abstract
Previous reports showed that scintigraphic localization of acute inflammation can be achieved using autologous leukocytes labeled in vitro with 99mTc-sulfur colloid (TcSC). The technique is limited by a marked accumulation of radioactivity in the lungs and liver of normal animals. A modified procedure was developed using preparations of TcSC of small particle size to label blood leukocytes in vitro. Markedly decreased levels of lung and liver radioactivity and elevated levels of blood radioactivity were found after i.v. infusion of autologous canine leukocytes labeled by this method. These leukocytes could be used to image areas of acute inflammation resulting from induction of septic or sterile venous thrombi.

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