Pili annulati: electron histochemical studies on affected hairs

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Abstract
In pili annulati all the normal layers within each cuticle cell are present, and a normal distribution of cystine are seen. The presence of well ordered macrofibrils, composed of microfibrils embedded in a cystine rich matrix, in both regions of the hair shaft indicates that normal keratinization can and does take place. The presence of electronopaque, cystine positive material at the intermacrofibrillar spaces was demonstrated. The presence of the cortical holes may be due in part to insufficient cortical material occupying available space and in part due to the dissolution of the intermacrofibrillar material, by water or other chemical agents diffusing through an apparently more permeable cuticle.

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