Decreased biliary excretion of cefamandole after percutaneous biliary decompression in patients with total common bile duct obstruction

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Abstract
The biliary penetration of cefamandole was studied in six patients with total biliary obstruction before and after placement of a transhepatic bile drainage catheter. Biliary levels of cefamandole remained depressed even when the drug was administered as late as 7 days after decompression of the biliary tract.