Joint modelling of multivariate longitudinal profiles: pitfalls of the random‐effects approach
- 24 September 2004
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 23 (20) , 3093-3104
- https://doi.org/10.1002/sim.1885
Abstract
Due to its flexibility, the random-effects approach for the joint modelling of multivariate longitudinal profiles received a lot of attention in recent publications. In this approach different mixed models are joined by specifying a common distribution for their random-effects. Parameter estimates of this common distribution can then be used to evaluate the relation between the different responses. Using bivariate longitudinal measurements on pure-tone hearing thresholds, it will be shown that such a random-effects approach can yield misleading results for evaluating this relationship. Copyright © 2004 John Wiley & Sons, Ltd.Keywords
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