Systemic Immunoprophylaxis of Nasal Respiratory Syncytial Virus Infection in Cotton Rats
- 1 February 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 171 (2) , 440-443
- https://doi.org/10.1093/infdis/171.2.440
Abstract
The cotton rat model was used to test whether systemically administered immunoglobulin could protect nasal tissues against low challenge doses of respiratory syncytial virus (RSV). Animals were pretreated by intraperitoneal injection of human immunoglobulin with moderate (1:2226) or high (1:15,000) neutralizing antibody titers to RSV (day 0), challenged intranasally with RSV Long at doses ranging from 101 to 105 pfu (day 1), and sacrificed for virus titration (day 5). Pretreatment with moderate-titer immunoglobulin effected complete or near complete nasal protection against low to moderate (101 -103 pfu) RSV challenge doses and a significant reduction in nasal RSV titers at high (104 -105 pfu) challenge doses. Pretreatment with high-titer immunoglobulin effected near complete nasal protection at an RSV challenge dose of 103 pfu and highly significant and significant reductions in nasal RSV titers at challenge doses of 104 and 105 pfu, respectively. Immunoprophylaxis effected complete or near complete pulmonary protection at all RSV challenge doses.Keywords
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