Mesonephric Adenocarcinoma of the Bladder

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Abstract
Mesonephric adenocarcinoma of the bladder may be the malignant counterpart of nephrogenic adenoma. The 3rd known case of this invasive, well differentiated, tubular neoplasm resembling nephrogenic adenoma was reported. The invasive potential of nephrogenic neoplasms has altered the approach to the management of these lesions. Nephrogenic adenoma and mesonephric adenocarcinoma appear cytologically similar on a superficial bladder biopsy. The latter is excluded by deeper bladder biopsies. Muscular invasion may indicate a more aggressive behavior and may require radical cystectomy for cure.