Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young
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- 27 September 2001
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 345 (13) , 971-980
- https://doi.org/10.1056/nejmra002168
Abstract
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritance, an onset usually before the age of 25 years and frequently in childhood or adolescence, and a primary defect in the function of the beta cells of the pancreas. MODY can result from mutations in any one of at least six different genes (Table 1). One of these genes encodes the glycolytic enzyme glucokinase (associated with MODY 2),3 and the other five encode transcription factors: hepatocyte nuclear factor (HNF) 4α (associated with MODY 1),4 HNF-1α (MODY . . .Keywords
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