Studies on the Coagulation of Chicken Blood. I. Factors which Limit Plasma Coagulation Rate during Vitamin K Deficiency and Treatment with Coumarin Drugs.

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Abstract
It is shown that the coagulation time of vitamin K-deficient and dicumarol or coumachlor plasmas is determined by the concentrations of three different types of factors (x-, [delta] - and [phi] -factors). A method for assay of these factors is described. Coagulation tests with thromboplastin, RVVcephalin or cephalin alone, are all sensitive to x- and -factors. The activity measured as [phi]p -factor activity, in the three different coagulation systems, probably includes both system specific entities and entities, common to all three coagulation systems. The relation of these coagulation factors to well-established human coagulation factors is discussed.