Hyperinsulinemia and Macrosomia

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Abstract
Macrosomia is a characteristic feature of diabetic pregnancy. The infants of mothers with diabetes mellitus (especially those with poorly controlled insulin-dependent diabetes or gestational diabetes) have increased body fat and selective organomegaly, including cardiomegaly, but Normal-Sized brains and kidneys.1 In contrast, infants whose large size at birth is due to genetic reasons are proportional.Pedersen proposed more than 35 years ago that macrosomia was due to fetal hyperinsulinism.2 This proposal was based primarily on his study of maternal and infant blood glucose concentrations and was supported by the findings of pancreatic-islet hypertrophy and beta-cell hyperplasia in the infants. Careful analysis . . .