Cortical Granule Release in Human Follicular Oocytes1

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Abstract
Cortical granule release is described in human oocytes removed from their follicles after induction of their meiotic maturation by human gonadotropins. This reaction is characterized ultrastructurally by modification of dense cortical granules, liberation of their contents into the perivitelline space, formation of numerous bristle coated vesicles and dissolution of the inner part of the zona pellucida. The significance of cortical granule release in follicular oocytes is discussed.