Growth Self-Incitement in Murine Melanoma B16: A Phenomenological Model
- 31 August 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4665) , 930-932
- https://doi.org/10.1126/science.6382606
Abstract
The growing murine melanoma B16 secretes increasing quantities of a substance or substances immunologically cross-reactive with insulin. The elevated concentrations of these substances in blood are accompanied by a decrease in blood glucose concentration and release of growth hormone, which is followed by increased tumor growth. By use of a phenomenological model based on these data, we show that B16 incites its own growth by positive feedback.Keywords
This publication has 21 references indexed in Scilit:
- Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virusNature, 1983
- Correlation of substance(s) immunologically cross-reactive with insulin, glucose and growth hormone in Hodgkin lymphoma patientsCancer Letters, 1982
- Autocrine Secretion and Malignant Transformation of CellsNew England Journal of Medicine, 1980
- Growth and treatment of B-16 melanoma in hyperglycemic miceZeitschrift für Die Gesamte Experimentelle Medizin, 1980
- REVIEW THE BIOSYNTHESIS OF HORMONES BY NON-ENDOCRINE TUMOURS-A REVIEWJournal of Endocrinology, 1975
- Effect of hypophysectomy on a virus-induced T-cell leukaemiaNature, 1974
- Human leukemic cells: Effect of human growth hormoneExperimental Cell Research, 1973
- NORMAL AND ABNORMAL SECRETION OF GROWTH HORMONE*Annals of the New York Academy of Sciences, 1968
- Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic RatsDiabetes, 1963
- Specific determination of blood glucose with o-toluidineClinica Chimica Acta; International Journal of Clinical Chemistry, 1962