AKAP79 and the evolution of the AKAP model
Open Access
- 26 June 2000
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 476 (1-2) , 58-61
- https://doi.org/10.1016/s0014-5793(00)01671-9
Abstract
A molecular explanation for the specificity of the cAMP‐dependent protein kinase (PKA) can be provided by its compartmentalization through association with A‐kinase‐anchoring proteins (AKAPs). Structural and functional studies have led to the development of an anchoring model proposing that AKAPs contain a common PKA binding domain and a unique subcellular targeting domain. The discovery that AKAPs can bind other signaling enzymes led to the addition of a third property, that of scaffolding molecule. Recent research has now expanded the role of AKAPs to members of multiunit complexes containing both upstream activators and downstream targets.Keywords
This publication has 43 references indexed in Scilit:
- A Role for AKAP (A Kinase Anchoring Protein) Scaffolding in the Loss of a Cyclic Adenosine 3',5'-Monophosphate Inhibitory Response in Late Pregnant Rat MyometriumMolecular Endocrinology, 1999
- Protein Kinase A Anchoring to the Myometrial Plasma Membrane Is Required for Cyclic Adenosine 3',5'-Monophosphate Regulation of Phosphatidylinositide TurnoverEndocrinology, 1999
- Modulation of Ion Channels: A “Current” View of AKAPsNeuron, 1999
- Protein kinase C: Ports of anchor in the cellCurrent Biology, 1996
- The postsynaptic density: A subcellular anchor for signal transduction enzymesCellular Signalling, 1995
- Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring ProteinScience, 1995
- Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neuronsNature, 1994
- Blotting and band-shifting: techniques for studying protein-protein interactionsTrends in Biochemical Sciences, 1992
- Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein KinaseScience, 1991
- Studies on the Mechanism of Hormone ActionScience, 1972