Abolition of autoregulation of renal blood flow by acetylcholine

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Abstract
In order to study the mechanism of autoregulation of renal blood flow, 36 mongrel dogs were connected in parabiosis according to the Brull method. The following determinations were made: a) flow/pressure curves in innervated and denervated kidneys and b) acetylcholine and arterenol infusion in innervated kidneys. The critical closing pressure and the "run-off" index were also determined in all cases. The results of these experiments show the existence of renal blood flow autoregulation in innervated, denervated, and arterenol-infused kidneys, and the abolition of the autoregulatory mechanism in the acetylcholine-infused kidneys. The run-off index showed a better correlation with renal resistance than with critical closing pressure.