Influence of X-Irradiation on Experimental Allergic Encephalomyelitis in Rats

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Abstract
Irradiation with X-rays reduced the incidence of experimental allergic encephalomyelitis (EAE) in rats sensitized in a relatively short time interval after irradiation and (concomitantly) postponed the onset of disease. By increasing the time interval between irradiation and sensitization (10-14 days), the normal incidence of disease was reached. At the same time, none of the sick animals was overcome by disease. Rats irradiated following sensitization developed EAE after a slight delay but with increased lethality. The lethal outcome was greater when the time interval between these 2 events was shorter. Sensitized nonirradiated and paralyzed rats succumbed to EAE only if paralysis occurred within the 1st 13 days. In rats sensitized prior to irradiation, the lethal outcome of disease was observed even in animals developing EAE symptoms within a 20-day period following sensitization.