Lewis Acid-Mediated Selective Removal of N-tert-Butoxycarbonyl Protective Group (t-Boc)
- 1 January 1999
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1999 (1) , 66-68
- https://doi.org/10.1055/s-1999-3694
Abstract
A simple and efficient method for the selective cleavage of N-Boc protective groups from amines employing Lewis acid aluminum chloride, is described. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.Keywords
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