Factor(s) from Ehrlich Ascites Cells Responsible for Delayed Rejection of Skin Allografts in Mice and Its Assay on Lymphocytes in Vitro

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Abstract
Cell free Ehrlich ascitic fluid from tumor bearing mice and the nutrient medium from Ehrlich cells maintained in vitro contain a factor(s) which when transferred to normal mice delays rejection of skin allografts and enhances the growth of a syngeneic transplantable tumor. Both types of prepartions inhibit DNA synthesis in lymphocytes stimulated by PHA. These results suggest that Ehrlich tumor cells release a factor which impairs the normal lymphocytic response to allo and tumor antigens.

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