Major Surgery and Scleromyxedema

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Abstract
To the Editor: Scleromyxedema (lichen myxedematosus) is a rare progressive skin disease characterized by deposition of mucin and proliferation of fibroblasts in the upper dermis. The fibroblasts contain abnormal fibrils, raising questions concerning their function.1 Since fibroblasts are important for wound healing, patients with scleromyxedema may not tolerate major surgery. A review of the literature, including the most recent comprehensive reports,2 , 3 since this disease was first described4 in 1906, reveals only one report of a patient subjected to a major surgical procedure. In 1946 a young woman had an abdominal hysterectomy, salpingo-oophorectomy, and appendectomy without apparent difficulty.5 Our recent surgical . . .

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