Hyperglycemic Coronary Perfusion

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Abstract
In a series of 84 animal experiments hyperglycemic perfusion of the heart gave significant protection to the anoxic heart. This protection was evaluated by ventricular function and contractile force studies and was observed after aortic occlusion at 37[degree], 28[degree] and 10[degree] C. Metabolic data revealed a considerable myocardial glucose uptake, higher coronary pH, higher pO2 and lower pCO2 in the glucose-perfused groups as compared to controls. A hypothesis for the protective effect may be an alteration in metabolic pathway and support of the myocardial enzyme systems associated with high glucose concentration and utilization.