Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia
- 29 January 1981
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 138 (1) , 46-50
- https://doi.org/10.1192/bjp.138.1.46
Abstract
Summary: Physostigmine (0.25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia. Significant improvement was seen on a picture recognition test with physostigmine 0.375 mg and arecholine 4 mg. A trend towards improvement was also seen with physostigmine 0.25 mg and 0.75 mg, and arecholine 2 mg. For the majority of the patients improvement was only slight but in two patients it was clear cut and consistent.This publication has 25 references indexed in Scilit:
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