Efficient curing of anEscherichia coliF-prime plasmid by phenothiazines
- 1 August 1975
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 26 (1) , 109-111
- https://doi.org/10.1017/s0016672300015895
Abstract
SUMMARY: Chlorpromazine and several other phenothiazines at sub-bacteriocidal concentrations were found to cure anEscherichia coliF′lac+strain of its plasmid efficiently. Curing was most efficient at high pH and in complex medium when 70% or more of the bacteria were plasmid-free after 24 h growth of cultures in the presence of the drug.Keywords
This publication has 5 references indexed in Scilit:
- Phenothiazine drugs: structure-activity relationships explained by a conformation that mimics dopamine.Proceedings of the National Academy of Sciences, 1975
- The antibacterial action and R-factor-inhibiting activity by chlorpromazineCellular and Molecular Life Sciences, 1975
- Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic DrugsProceedings of the National Academy of Sciences, 1974
- Fluorescence of complexes of acridine dye with synthetic polydeoxyribonucleotides: A physical model of frameshift mutationJournal of Molecular Biology, 1974
- THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1960