Suppression of Thymidine Incorporation into the Gastric Mucosa of Cortisone-Treated Rats: Possible Relation to Glucocorticoid-Induced Gastric Ulceration
- 1 May 1973
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 92 (5) , 1322-1327
- https://doi.org/10.1210/endo-92-5-1322
Abstract
The administration of cortisone acetate to young rats results within 24 hr in a marked suppression of thymidine incorporation into the DNA of the gastric mucosa. The dose of hormone required for the acute suppression of thymidine incorporation is greater for gastric mucosa than it is for liver, and, as is also the case with liver, sensitivity to suppression is found to decrease with animal age. In striking contrast to their effects on the gastric mucosa, even large doses of hormone have no acute effect on thymidine incorporation by jejunal mucosa. It is suggested that a decrease in the normal rate of turnover of the gastric mucosa and a resulting increase in the duration of exposure of mucosal cells to the luminal environment may play a role in the phenomenon of glucocorticoid—induced gastric ulceration. (Endocrinology92: 1322, 1973)Keywords
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