The Correlation between Gastric Acid Secretion and Histology of Fundic and Antral Gland Area

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Abstract
Correlative studies were performed in 92 patients with gastric or duodenal ulcer, chronic gastritis, or diabetes mellitus. The basal acid secretion and that stimulated maximally by histamine or pentagastrin infusion decreased significantly with increasing severity of atrophic changes in the fundic gland area. Histological changes of antral mucosa were in 72 per cent of cases of similar degree as in fundic gland area. In the remainder of patients antral mucosa showed inflammatory or atrophic changes more advanced than the fundic gland area.