Zunahme des Leberblutflusses unter Nifedipin

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Abstract
The hepatic hemodynamic effect of 20 mg sublingual nifedipine was evaluated in 15 patients (13 men, 2 women) during heart catheterization. The liver blood flow was measured 10 min after administration of nifedipine by continuous thermodilution (Baim coronary sinus flow analyzer). Nifedipine was associated with a decrease in systolic blood pressure (from 156+/−14 to 138+/−13 mmHg), an increase in heart rate from (73+/−13 to 81+/−8.6 beats/min), and increase in cardiac output (from 6.0+/−1.6 to 6.5+/−1.3 l/min). In 2/15 patients no significant change was derived. The liver blood flow increased in 13/15 patients from 218+/−171.7 to 336.7+/−247.7 ml/min (22%–194%,P<0.01). The study demonstrates that the vasodilation of nifedipine involves the hepatic circulation. If the hepatic clearance of drugs is high and flow dependent, nifedipine-induced increase of hepatic blood flow may impair drug clearance.