Synthesis and antiinflammatory activity of some 1,2,3- and 1,2,4-triazolepropionic acids

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Abstract
All possible nonadjacent phenyltriazolepropionic acids were synthesized and tested for antiinflammatory activity in the rat. Two of the isomers displayed activity approximately equal to phenylbutazone: the 4-phenyl-1,2,3-triazole-2-propionic acid and its reverse counterpart, 2-phenyl-1,2,3-triazole-4-propionic acid. The other 5 isomers were inactive. Since these 7 acids are geometrically congruent and possess similar lipophilic characters, antiinflammatory activity must depend on some property that is a function of how the C and N atoms are arranged in the triazole ring.