‘Pulsed’ immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease

Abstract
‘Pulsed’ immunosuppressive therapy, using methylprednisolone with or without cyclophosphamide, has effectively controlled severe destructive corneal and scleral disease that had been unresponsive to oral steroids. Thirty-seven patients have been treated in this manner and the results, complications and possible mechanism of action are discussed.