THE CORRELATION OF THE CIRCULATING POLYMORPHONUCLEAR LEUCOCYTES (NEUTROPHILES) WITH THE ADRENAL ASCORBIC ACID IN THE RAT

Publisher Website
Google Scholar
Abstract
Clinical and experimental animal data reported in the past few years have indicated that there probably is a functional relationship between the activity of the adrenal cortex and the hematologic picture of individuals. Alterations in the normal white blood cell composition were reported in endocrinopathies of the adrenal cortex and the pituitary-adrenal cortex system (Baize, Reifenstein and Albright, 1946). The induction of a change from the normal white blood cell picture following ACTH in patients with adequate adrenal-cortical function has been reported by Forsham, Thorn, Prunty and Hills (1948). The hematologic changes observed in humans following alteration of adrenal-cortical function as a result of pathology or experimentally were predictable from the investigations on lower mammals by Dougherty and White (1944, 1947). The latter investigators have shown that increased activity of the adrenal cortex, particularly secretions of the 11-oxysteroid type, results in a lymphopenia specifically and a non-specific rise in the polymorphonuclear leucocytes.