Reversal of Central Anticholinergic Syndrome in Man by Physostigmine
- 25 November 1968
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 206 (9) , 1963-1965
- https://doi.org/10.1001/jama.1968.03150090039008
Abstract
Physostigmine salicylate in doses of 1 to 2 mg administered parenterally was found to be an effective antidote to intoxication with centrally active anticholinergic agents. Confusion, agitation, hallucinations, stupor, ataxia, dysarthria, and other symptoms were promptly reversed in 26 consecutive patients in whom toxic reactions developed after receiving scopolamine, atropine, or drugs for Parkinson's disease. Physostigmine deserves a place in therapeutics as an antidote to anticholinergic intoxication.Keywords
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