ANTIEMETIC EFFICACY OF PROPHYLACTIC ONDANSETRON IN LAPAROSCOPIC SURGERY: RANDOMIZED, DOUBLE-BLIND COMPARISON WITH METOCLOPRAMIDE

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Abstract
In a randomized, double-blind study, we have compared the prophylactic antiemetic efficacy of ondansetron with that of metoclopramide in 123 patients undergoing general anaesthesia for day case gynaecological laparoscopic surgery. The patients received either i.v. ondansetron 4 mg or metoclopramide 10 mg immediately before a standard anaesthetic. The number of patients with no nausea or vomiting in the ondansteron group was 50 (82%) compared with 29 (47%) in the meto clopramide group (PPBr. J. Anaesth. 1993; 71: 845–848)