True histiocytic neoplasm of Langerhans' cell type

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Abstract
Malignant histiocytic neoplasms of dendritic cell lineage are rare and most are derived from the dendritic cells of the T‐cell and B‐cell areas of the lymph node, respectively. Only one case of a malignant histiocytic neoplasm of Langerhans' cells, the dendritic cell of the skin, has been reported. We report the occurrence of a true histiocytic neoplasm of Langerhans' cell type in a 23‐year‐old female patient. The diagnosis of this highly aggressive neoplasm is supported by histochemical, immunohistochemical, ultrastructural, and genotypic analysis—techniques which allow differentiation from malignant melanoma and large cell anaplastic lymphoma.