EXPERIMENTAL COPPER DEFICIENCY IN LABORATORY MICE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 32  (5) , 491-494
Abstract
Cu deficiency was produced in weanling C57BL/6J and Hap:(ICR) mice that were fed a milk-sucrose based diet supplemented with appropriate vitamins, minerals and amino acids. Growth retardation, decreased hematocrit, lethargy, dyspnea, achromotrichia and high mortality (in ICR mice) were apparent in Cu-deficient mice. Cardiac enlargement, hemopericardium, hemothorax and pleural effusion were observed at necropsy. Thrombosis of the atria, myocardial degeneration, necrosis and sites of myocardial rupture were observed at histopathologic examination.

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