Altered glucose metabolism in microvessels from patients with Alzheimer's disease
- 1 July 1989
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 26 (1) , 91-94
- https://doi.org/10.1002/ana.410260114
Abstract
Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.Keywords
This publication has 22 references indexed in Scilit:
- BLOOD-BRAIN BARRIER TRANSPORT OF NUTRIENTSNutrition Reviews, 2009
- Phosphofructokinase activity in the brain in Alzheimer's diseaseAnnals of Neurology, 1987
- Abnormal Temporal Lobe Response in Alzheimer's Disease during Cognitive Processing as Measured by 11C-2-Deoxy-D-Glucose and PETJournal of Cerebral Blood Flow & Metabolism, 1987
- Specialized Properties and Solute Transport in Brain CapillariesAnnual Review of Physiology, 1986
- Alzheimer's DiseaseNew England Journal of Medicine, 1986
- Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]DeoxyglucoseJournal of Cerebral Blood Flow & Metabolism, 1985
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- Neurochemical enzyme changes in Alzheimer's and Pick's diseaseArchives of Gerontology and Geriatrics, 1984
- Positron Emission Tomography and Computed Tomography Assessments of the Aging Human BrainJournal of Computer Assisted Tomography, 1984
- Neurotransmitter-related enzymes in senile dementia of the alzheimer typeBrain Research, 1979