Formation of nucleoside 5′-phosphoramidates under potentially prebiological conditions
- 1 June 1977
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 10 (2) , 137-154
- https://doi.org/10.1007/bf01751807
Abstract
Summary Adenosine 5′-phosphoramidates form when solutions containing adenosine 5′-polyphosphates pnA (n ≧ 3) or P1, P2-diadenosine 5′-diphosphate and amines are allowed to dry out. Mg ions catalyze these reactions. We have studied systems containing ammonia, imidazole, glycine, ethylenediamine and histamine. The yields of adenosine 5′-phosphoramidates range from 10–50 % based on the nucleotide. The prebiotic significance of the reactions is discussed.Keywords
This publication has 18 references indexed in Scilit:
- Polymerization of nucleotide analogues I: Reaction of nucleoside 5′-phosphorimidazolides with 2′-amino-2′-deoxyuridineJournal of Molecular Evolution, 1976
- Formation of nucleoside 5′-polyphosphates under potentially prebiological conditionsJournal of Molecular Evolution, 1976
- Formation of nucleoside 5′-polyphosphates from nucleotides and trimetaphosphateJournal of Molecular Evolution, 1975
- Prebiotic peptide-formation in the solid stateJournal of Molecular Evolution, 1975
- Prebiotic peptide-formation in the solid stateJournal of Molecular Evolution, 1975
- Prebiotic Activation ProcessesNature, 1973
- Ammonia Photolysis and the Role of Ammonia in Chemical RevolutionNature, 1972
- Hypochromicity of oligo- and polynucleotidesBiochimica et Biophysica Acta, 1962
- The Synthesis of Adenosine-5' and Uridine-5' PhosphoramidatesJournal of the American Chemical Society, 1958
- Nucleoside Polyphosphates. VI.1 An Improved and General Method for the Synthesis of Ribo- and Deoxyribonucleoside 5'-TriphosphatesJournal of the American Chemical Society, 1958