Ketoconazole Therapy for Fungal Urinary Tract Infections

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Abstract
Ketoconazole was used in 11 patients to treat 12 episodes of fungal urinary infections, 6 in the upper urinary tract and 6 presumed to be in the lower urinary tract. Five patients had catheters in place. Of the 12 infections, 8 were caused by Candida spp., 1 by mixed C. tropicalis and Torulopsis glabrata and 3 by T. glabrata. Ketoconazole was administered orally at doses of 200-800 mg/day for courses ranging from 5 days to > 2 yr. Five episodes of Candida urinary tract infection resolved in association with ketoconazole therapy; only one of the T. glabrata infections improved. Apparently, ketoconazole may be of some benefit in yeast urinary tract infections. The role of ketoconazole in relation to other antifungal drugs is not yet clear.