Prebiotic Synthesis: Phosphorylation in Aqueous Solution
- 5 July 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 161 (3836) , 64-66
- https://doi.org/10.1126/science.161.3836.64
Abstract
Formation of uridine-5′-phosphate from uridine and inorganic phosphate in aqueous solution is effected by the following condensing agents: cyanogen, cyanoformamide, cyanate, cyanamide, thioformate, ethylisocyanide, and a water-soluble carbodiimide. The yields are always small, even when a large excess of condensing agent is used. The cyclization of uridine-3′-(2′)-phosphate occurs under the same conditions but in much greater yield.Keywords
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