An approach to peripheral vasodilator-.beta.-adrenergic blocking agents

1 August 1977

journal article
research article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 20 (8) , 1024-1029
https://doi.org/10.1021/jm00218a007

Abstract

The syntheses of 2-phenyl- and 2-pyridyl-4-trifluoromethylimidazoles having a 3-tert-butylamino-2-hydroxypropoxy moiety attached to the aryl or heteroaryl substituent are described. Structure-activity relationships based on results from an evaluation of these compounds for antihypertensive, vasodilating and .beta.-adrenergic blocking activities in dogs and spontaneously hypertensive rats are discussed.

Keywords

ADRENERGIC