Comparison between the 133Xe clearance method and the microsphere technique in cerebral blood flow determinations in the dog.

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Abstract
The 133Xe clearance method and the microsphere technique (15 .mu.m spheres) for cerebral blood flow determination were compared in 15 dogs. The 133Xe clearance curve obtained from sampling dorsal sagittal sinus blood after left ventricular injection showed 2 or 3 components. Blood flow calculated from the 1st component was correlated with the average gray matter blood flow through the caudate nucleus, the cortical gray, and the thalamus calculated from the microsphere data. The 2nd component of the 133Xe curve correlated with the white matter blood flow measured with microspheres. In 7 of 15 experiments there was a 3rd component in the 133Xe clearance curve. The blood flow obtained from the 3rd component showed a close correlation with extracranial muscle blood flow determined with microspheres. The mean cerebral blood flow measured with the 133Xe clearance method agreed with that obtained by the microsphere technique. After the injection of 133Xe into extracranial muscles the slope of the clearance curve obtained from the dorsal sagittal sinus correlated with that of the 3rd component after left ventricular injection. Apparently regional cerebral blood flows measured with 15 .mu.m microspheres can be correlated with findings from various components of the simultaneous 133Xe clearance. Extracranial muscle blood flow must be considered when analyzing the 133Xe clearance curve.