Development of a P-Glycoprotein Knockout Model in Rodents to Define Species Differences in its Functional Effect at the Blood–brain Barrier
- 1 September 2006
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 95 (9) , 1944-1953
- https://doi.org/10.1002/jps.20658
Abstract
No abstract availableKeywords
This publication has 48 references indexed in Scilit:
- P-Glycoprotein and Mutlidrug Resistance-Associated Proteins Limit the Brain Uptake of Saquinavir in MiceThe Journal of Pharmacology and Experimental Therapeutics, 2005
- Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoproteinEuropean Journal Of Cancer, 2004
- Utility of Mdr1-Gene Deficient Mice in Assessing the Impact of P-glycoprotein on Pharmacokinetics and Pharmacodynamics in Drug Discovery and DevelopmentCurrent Drug Metabolism, 2003
- The Role of Drug Transporters at the Blood-Brain BarrierAnnual Review of Pharmacology and Toxicology, 2003
- Role of P-Glycoprotein in PharmacokineticsClinical Pharmacokinetics, 2003
- A general pattern for substrate recognition by P‐glycoproteinEuropean Journal of Biochemistry, 1998
- Blood-brain barrier function of P-glycoproteinAdvanced Drug Delivery Reviews, 1997
- P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cellsLife Sciences, 1992
- Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.Proceedings of the National Academy of Sciences, 1990
- Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.Proceedings of the National Academy of Sciences, 1987