Concentration of Cyclic 3′: 5′‐Adenosine Monophosphate and Glycogen Metabolism in the Liver

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Abstract
The increase in the concentration of cyclic adenosine 3′: 5′‐phosphate in the liver after the administration of a small dose of glucagon precedes the inactivation of glycogen synthetase by 1–2 min. This sequence of events is in agreement with the role of the nucleotide as second messenger in the hormonal action. The increase is dose dependent and is the same in control and prednisolone treated mice.Treatment of mice with glucose or prednisolone causes a slight decrease in the concentration of cyclic adenosine 3′: 5′‐phosphate in the liver. The minuteness of this effect is in contrast with the large activation of glycogen synthetase that occurs under the same conditions.