Intracerebral Growth and Treatment of Leukemia L1210

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Abstract
Intracerebral (IC) injection of lymphoid leukemia material (LI210) into DBA/2J and the hybrid CDBA mouse was followed by growth in the brain, diffuse infiltrates in the arachnoid, and rapidly became systemic. Bioassay of brain tissue from mice implanted IC showed that leukemic titer in brain increased rapidly. Infiltration of spleen and blood occurred earlier in IC implanted mice in contrast to subcutaneously (SC) implanted mice. Brain of SC implanted mice became infiltrated by the 8th day. Microscopic examination following IC implantation of LI210 showed diffuse infiltration by leukemic cells in the subarachnoid spaces, small nodules of leukemic cells in the ventricles, and occasional IC blood vessels surrounded by a cuff of leukemic cells. Treatment of IC implanted mice with amethopterin and 3'',5''-dichloroamethopterin caused substantial increases in survival time, indicating that both drugs might be capable of penetrating the blood-brain barrier.

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