Thyroid Cancer in Rats From Ethylene Thiourea Intake
- 1 August 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 49 (2) , 583-584
- https://doi.org/10.1093/jnci/49.2.583
Abstract
Administration of 350 and 175 parts per million ethylene thiourea in the diet of male and female Charles River CD rats led to a dose-related induction of follicular and papillary thyroid cancers, with pulmonary metastases, and of related lesions such as thyroid solid-cell adenomas and hyperplastic and simple goiter. The first tumor was found after 68 weeks; most cancers occurred after 18–24 months when the study was terminated. Control rats did not show these lesions.Keywords
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