Susceptibility of Rickettsia conorii and R. rickettsii to pefloxacin, in vitro and in ovo
- 1 March 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 19 (3) , 303-305
- https://doi.org/10.1093/jac/19.3.303
Abstract
The activity of pefloxacin against Rickettsia conorii and R. rickettsii was determined by several methods. The mean survival time of embryonated eggs infected with R. conorii was increased by pefloxacin 50 μg/egg; plaque formation in Vero cells was inhibited by 1 mg/1. In a microplate assay, the MIC of pefloxacin was 0.5 mg/1 for R. conorii and 1 mg/l for R. rickettsii. The results support the use of pefloxacin in treating spotted fever rickettsioses.Keywords
This publication has 1 reference indexed in Scilit:
- Mediterranean Spotted Fever: Clinical, Laboratory and Epidemiological Features of 199 CasesThe American Journal of Tropical Medicine and Hygiene, 1986