Secretin-like bioactivity in the duodenal mucosa in patients with peptic ulcer and chronic pancreatitis.

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Abstract
Duodenal mucosa biopsy specimens were assayed to determine their secretin-like activity in 9 controls, 9 gastric ulcer patients, 19 duodenal ulcer patients, 4 gastric and duodenal ulcer patients and 13 chronic pancreatitis patients. The bioassay of secretin was done on the pancreatic secretion in anesthetized rats. The sensitivity was in the order of 0.0625 CHR unit/rat (4 ng/rat). Between 0.0625-0.5 CHR units, a satisfactory dose dependency was recognized. Duodenal mucosal secretin-like activity in patients with gastric ulcer was the same as that in the controls, but elevated in 32% of the patients with duodenal ulcer, 50% of those with gastric and duodenal ulcer and 8% of those with chronic pancreatitis. High secretin-like activity in duodenal ulcer patients might be related to hypersecretion of gastric acid characteristic of this disease. There was no correlation between gastric acid secretion and secretin-like activity in the duodenal mucosa.