BONE-MARROW TRANSPLANTATION FOR LEUKEMIA FOLLOWING A NEW BUSULFAN AND CYCLOPHOSPHAMIDE REGIMEN

  • 1 November 1987
    • journal article
    • research article
    • Vol. 70  (5) , 1382-1388
Abstract
Busulfan 16 mg/kg and cyclophosphamide 120 mg/kg were used as conditioning prior to allogeneic marrow transplantation in 50 adult patients with acute nonlymphocytic leukeamia (ANLL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML). A standard risk group of 20 patients included those with acute leukemia in remission and CML in chronic phase. A high-risk group of 30 patients included individuals with refractory acute leukemia, acute leukemia in relapse, acute leukemia following preleukemia, and CML in accelerated and blastic phase. Complete remission and sustained complete engraftment were acheived in all evaluable patients. The duration of aplasia was remarkedly short (median of 8 days), resulting in a low infection rate during the period of neutropenia, a reduced need for blood product support, and a short length of hospital stay. Three-year actarial relapse-free survival in both standard-risk (88.9% .+-. 10.5%) and high-risk (50.5% .+-. 9.6%) groups compares favorably with that reported with total body irradiation (TBl) containing regimens.