Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
Open Access
- 9 May 2010
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 16 (6) , 662-664
- https://doi.org/10.1038/nm.2145
Abstract
Adeno-associated virus serotype 6–mediated transduction requires the epidermal growth factor receptor. A key step in gene therapy is the efficient transfer of genes in a cell type– and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably functions as a co-receptor for AAV6.Keywords
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