Antigen presentation to naive CD4 T cells in the lymph node
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- 1 August 2003
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 4 (8) , 733-739
- https://doi.org/10.1038/ni957
Abstract
Although the presentation of peptide–major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.Keywords
This publication has 77 references indexed in Scilit:
- Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell ToleranceThe Journal of Experimental Medicine, 2002
- Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in VivoThe Journal of Experimental Medicine, 2001
- In Vivo Activation of Antigen-Specific CD4 T CellsAnnual Review of Immunology, 2001
- Visualizing the generation of memory CD4 T cells in the whole bodyNature, 2001
- T-Cell Function and Migration — Two Sides of the Same CoinNew England Journal of Medicine, 2000
- Dendritic cells and the control of immunityNature, 1998
- A Subset of Splenic Macrophages Process and Present Native Antigen to Naive Antigen-Specific CD4+T-Cells from Mice Transgenic for an αβ T-Cell ReceptorCellular Immunology, 1995
- Osteopetrotic (op/op) Mice Deficient in Macrophages Have the Ability to Mount a Normal T-Cell-Dependent Immune ResponseCellular Immunology, 1995
- A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.The Journal of Experimental Medicine, 1994
- The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light‐microscopic immunocytochemical studies of mouse spleen, lymph node, and peyer's patchJournal of Anatomy, 1984