An algorithm for nasal pungency thresholds in man
- 10 March 1998
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 72 (4) , 227-232
- https://doi.org/10.1007/s002040050493
Abstract
Where the independent variables are solute descriptors: 2 H is the dipolarity/polarizability, Σ2 H and Σ2 H are the overall or effective hydrogen-bond acidity and basicity, and L 16 is the solute Ostwald solubility coefficient on hexadecane at 25 °C. Surprisingly, the aliphatic aldehydes and carboxylic acids fit the correlation and with respect to nasal pungency thresholds in man for brief (1–3 s) presentations must be regarded as `nonreactive' compounds. It is suggested mere transport of the compound from the air stream to the receptor area largely determines the potency to produce pungency. Various chemical properties of the receptor area are deduced from the coefficients in Eq. i.Keywords
This publication has 0 references indexed in Scilit: